key biopharmaceuticals for vision

Selected References: Deprenyl Compounds and Neuroprotection

  • Buys, Y.M., G.E. Trope, and W.G. Tatton, (-)-Deprenyl increases the survival of rat retinal ganglion cells after optic nerve crush. Curr Eye Res, 1995. 14(2): p. 119-126.
  • Delaney, C.L., J.W. Russell, H.L. Cheng, and E.L. Feldman, Insulin-like growth factor-I and over-expression of Bcl-xL prevent glucose-mediated apoptosis in Schwann cells. J Neuropathol Exp Neurol, 2001. 60(2): p. 147-60.
  • Gill, J.S. and A.J. Windebank, Cisplatin-induced apoptosis in rat dorsal root ganglion neurons is associated with attempted entry into the cell cycle. J Clin Invest, 1998. 101(12): p. 2842-50.
  • Greene, D.A., M.J. Stevens, I. Obrosova, and E.L. Feldman, Glucose-induced oxidative stress and programmed cell death in diabetic neuropathy. Eur J Pharmacol, 1999. 375(1-3): p. 217-23.
  • Hotta, N., New concepts and insights on pathogenesis and treatment of diabetic complications: polyol pathway and its inhibition. Nagoya J Med Sci, 1997. 60(3-4): p. 89-100.
  • Jaffey, P.B. and B.B. Gelman, Increased vulnerability to demyelination in streptozotocin diabetic rats. J Comp Neurol, 1996. 373(1): p. 55-61.
  • Mittag, T.W., J. Danias, G. Pohorenec, H.M. Yuan, E. Burakgazi, R. Chalmers-Redman, S.M. Podos, and W.G. Tatton, Retinal damage after 3 to 4 months of elevated intraocular pressure in a rat glaucoma model. Invest Ophthalmol Vis Sci, 2000. 41(11): p. 3451-9.
  • Paterson I. A., Barber A. J., Gelowitz D. L., and Voll C. (1997) (-)Deprenyl reduces delayed neuronal death of hippocampal pyramidal cells. Neurosci Biobehav Rev. 21, 181-186.
  • Russell, J.W., K.A. Sullivan, A.J. Windebank, D.N. Herrmann, and E.L. Feldman, Neurons undergo apoptosis in animal and cell culture models of diabetes. Neurobiol Dis, 1999. 6(5): p. 347-63.
  • Tatton, W.G., R.M. Chalmers-Redman, and Tatton, N.A., Apoptosis and anti-apoptosis signalling in glaucomatous retinopathy. Eur J Ophthalmol, 2001. 11 Suppl 2: p. S12-22.
  • Tatton, N.A., G. Tezel, S.A. Insolia, S.A. Nandor, P.D. Edward, and M.B. Wax, In situ detection of apoptosis in normal pressure glaucoma. a preliminary examination. Surv Ophthalmol, 2001. 45(6 Suppl 1): p. S268-72.
  • Tatton W. G., Chalmers-Redman R. M. E., Ju W. J. H., Carlile G. W., Mammen M., and Tatton N. A. Propargylamines Induce Anti-Apoptotic New Protein Synthesis In Serum And NGF Withdrawn NGF-Differentiated PC12 Cells. J Pharmacol ExperTherapeut. 2002.
  • Srinivasan, S., M. Stevens, and J.W. Wiley, Diabetic peripheral neuropathy: evidence for apoptosis and associated mitochondrial dysfunction. Diabetes, 2000. 49(11): p. 1932-8.
  • Xu, L., J. Ma, G.M. Seigel, and J.X. Ma, l-Deprenyl, blocking apoptosis and regulating gene expression in cultured retinal neurons. Biochem Pharmacol, 1999. 58(7): p. 1183-90.

Selected References: PhotoTarget Technology

  • Asrani S, et al. Noninvasive visualization of the blood flow in the choriocapillaris of the normal rat. Invest Ophthalmol Vis Sci .1996. 37:312-7.
  • Asrani S, et al. Feasibility of laser-targeted photoocclusion of the choriocapillary layer in rats. Invest Ophthalmol Visual Sci. 1997. 38: p. 2702-10.
  • Guran T, Zeimer R, Shahidi M, Quantitative analysis of retinal hemodynamics using targeted dye delivery. Invest. Ophthal. 1990. 31: p. 2300-2306.
  • Nishiwaki H. Laser targeted photo-occlusion of rat choroidal neovascularization without collateral damage. Photochem Photobiol. 2002. 75; p. 149-158.
  • Rosenthal I, Phthalocyanines as photodynamic sensitizers. Photochem Photobiol. 1991;53:859-870.
  • Zeimer R, et al. A potential method for local drug and dye delivery in the ocular vasculature. Invest Ophthalmol Vis Sci. 1988. 29: p. 1179-83.
  • Zeimer R, et al. Visualization of the retinal microvasculature by targeted dye delivery. Invest Ophthalmol Vis Sci. 1990. 31:p. 1459-65.